Forschung

Die im Rahmen der Forschungstätigkeit von Dr. Yamazaki generierten Daten lieferten erste vielversprechende Resultate zur Wirksamkeit von Talidox® im lebenden Organismus. Nun ist es an InnoMedica, aus dieser Forschung ein pharmazeutisches Produkt zu machen und zum Patienten zu bringen. In Zusammenarbeit mit der Universität Mailand (Mario Negri Institut) werden präklinische Studien durchgeführt und die Forschungsresultate weiter elaboriert.

 

Wissenschaftliche Publikationen über Glykan-Targeting Technologie von unabhängigen Forschungsgruppen:

Allen, T. M. & Chonn, A. (1987). Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Letters, 223 (1): 42-46.

"Chang, H.-I., Cheng, M.-Y. & Yeh, M.-K. (2012). Clinically-proven liposome-based drug delivery: formulation, characterization, and therapeutic efficacy. 1: 195. doi:10.4172/scientificreports.195.

Clift, M. J. D., Dechézelles J.-F., Rothen-Rutishauser, B. & Petri-Fink, A. (2015). A biological perspective toward the interaction of theranostic nanoparticles with the bloodstream – what needs to be considered? Front Chem, 3: 7.

Huwyler, J. Drewe, J. & Krähenbühl, S. (2008). Tumor targeting using liposomal antineoplastic drugs. Int J Nanomedicine, 3(1): 21-9.

Jubeli, E., Moine, L., Vergnaud-Gauduchon, J. & Barratt, G. (2012). E-selectin as a target for drug delivery and molecular imaging. J Control Release; 158 (2): 194-206.

Jubeli, E., Moine, L., Nicolas, V. & Barratt, G. (2012). Preparation of E-selectin-targeting nanoparticles and preliminary in vitro evaluation. Int J Pharm; 426: 291-301.

Kateb, B., et al. (2011). Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy? Neuroimage; 54: S106-124.

Liu, F.-T. & Rabinovich, G. A. (2005). Galectins as modulators of tumour progression. Nature Reviews Cancer; 5: 29-41.

Madureira de-Freitas-Junior, J. & Morgado-Diaz, J. A. (2015). The role of N-glycans in colorectal cancer progression: Potential biomarkers and therapeutic applications. Oncotarget, Nov 2. [Epub ahead of print]

Pérez-Herrero, E. & Fernández-Medarde, A. (2015). Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. Eur J Pharm Biopharm, 93: 52-79.

Pinho, S.S. & Reis, C.A. (2015). Glycosylation in cancer: mechanisms and clinical implications. Nat Rev Cancer, 15 (9): 540-55.

Sun, T., Thang, Y. S., Pang, B., Hyun, D. C., Yang, M. & Xia, Y. (2014). Engineered nanoparticles for drug delivery in cancer therapy. Angew Chem Int Ed Engl, 53 (46): 12320-64.

Wicki, A.., Witzigmann, D., Balasubramanian, V. & Huwyler, J. (2015). Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications. J Control Release, 200: 138-57.

 

Wissenschaftliche Publikationen der Forschungsgruppe um Herrn Dr. Noboru Yamazaki:

Arakawa, Y., Hashida, N., Ohguro, N., Yamazaki, N., Onda, M., Matsumoto, S., Ohishi, M., Yamabe, K., Tano, Y., & Kurokawa, N. (2007). Eye-concentrated distribution of dexamethasone carried by sugar-chain modified liposome in experimental autoimmune uveoretinitis mice. Biomed Res-Tokyo; 28 (6): 331–4.

Hashida, N., Ohguro, N., Yamazaki, N., Arakawa, Y., Oiki, E., Mashimo, H., Kurokawa, N. & Tano, Y. (2008). High-efficacy site-directed drug delivery system using sialyl-Lewis X conjugated liposome. Exp Eye Res; 86 (1): 138-49.

Hirai, M., et al. (2010). E-selectin targeting to visualize tumors in vivo. Contrast Media Mol Imaging; 5 (2): 70-7.

Hirai, M., et al. (2010). Novel and simple loading procedure of cisplatin into liposomes and targeting tumor endothelial cells. Int J Pharm; 391 (1-2): 274-83.

Hirai, M., Minematsu, H., Kondo, N., Oie, K., Igarashi, K. & Yamazaki, N. (2007). Accumulation of liposome with Sialyl Lewis X to inflammation and tumor region: Application to in vivo bio-imaging. Biochem Bioph Res Co; 353 (3): 553-8.

Shimura, N., Sogawa, Y., Kawakita, Y., Ikekita, M., Yamazaki, N. & Kojima, S. (2002). Radioiodination of glycoprotein-conjugated liposomes by using the Bolton-Hunter reagent and biodistribution in tumor-bearing mice. Nucl Med Biol; 29 (4): 491-6.

Tsuruta, W., Tsurushima, H., Yamamoto, T., Suzuki, K., Yamazaki, N. & Matsumura, A. (2009). Application of liposomes incorporating doxorubicin with sialyl Lewis X to prevent stenosis after rat carotid artery injury. Biomaterials; 30 (1): 118-25.