The research data of Dr. Yamazaki animal studies provides us with promising results regarding the efficacy of Talidox® in the living organism. Now it is the job of InnoMedica to transform this research into a pharmaceutical product and bring it to the patients. In cooperation with the University of Milano (Mario Negri Institute) preclinical studies are conducted and research results further elaborated.


Scientific publications about InnoMedica’s targeting technology by independent research groups:

Allen, T. M. & Chonn, A. (1987). Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Letters, 223 (1): 42-46.

"Chang, H.-I., Cheng, M.-Y. & Yeh, M.-K. (2012). Clinically-proven liposome-based drug delivery: formulation, characterization, and therapeutic efficacy. 1: 195. doi:10.4172/scientificreports.195.

Clift, M. J. D., Dechézelles J.-F., Rothen-Rutishauser, B. & Petri-Fink, A. (2015). A biological perspective toward the interaction of theranostic nanoparticles with the bloodstream – what needs to be considered? Front Chem, 3: 7.

Huwyler, J. Drewe, J. & Krähenbühl, S. (2008). Tumor targeting using liposomal antineoplastic drugs. Int J Nanomedicine, 3(1): 21-9.

Jubeli, E., Moine, L., Vergnaud-Gauduchon, J. & Barratt, G. (2012). E-selectin as a target for drug delivery and molecular imaging. J Control Release; 158 (2): 194-206.

Jubeli, E., Moine, L., Nicolas, V. & Barratt, G. (2012). Preparation of E-selectin-targeting nanoparticles and preliminary in vitro evaluation. Int J Pharm; 426: 291-301.

Kateb, B., et al. (2011). Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy? Neuroimage; 54: S106-124.

Liu, F.-T. & Rabinovich, G. A. (2005). Galectins as modulators of tumour progression. Nature Reviews Cancer; 5: 29-41.

Madureira de-Freitas-Junior, J. & Morgado-Diaz, J. A. (2015). The role of N-glycans in colorectal cancer progression: Potential biomarkers and therapeutic applications. Oncotarget, Nov 2. [Epub ahead of print]

Pérez-Herrero, E. & Fernández-Medarde, A. (2015). Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. Eur J Pharm Biopharm, 93: 52-79.

Pinho, S.S. & Reis, C.A. (2015). Glycosylation in cancer: mechanisms and clinical implications. Nat Rev Cancer, 15 (9): 540-55.

Sun, T., Thang, Y. S., Pang, B., Hyun, D. C., Yang, M. & Xia, Y. (2014). Engineered nanoparticles for drug delivery in cancer therapy. Angew Chem Int Ed Engl, 53 (46): 12320-64.

Wicki, A.., Witzigmann, D., Balasubramanian, V. & Huwyler, J. (2015). Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications. J Control Release, 200: 138-57.


Scientific publications by the reasearch group of Dr. Noboru Yamazaki:

Arakawa, Y., Hashida, N., Ohguro, N., Yamazaki, N., Onda, M., Matsumoto, S., Ohishi, M., Yamabe, K., Tano, Y., & Kurokawa, N. (2007). Eye-concentrated distribution of dexamethasone carried by sugar-chain modified liposome in experimental autoimmune uveoretinitis mice. Biomed Res-Tokyo; 28 (6): 331–4.

Hashida, N., Ohguro, N., Yamazaki, N., Arakawa, Y., Oiki, E., Mashimo, H., Kurokawa, N. & Tano, Y. (2008). High-efficacy site-directed drug delivery system using sialyl-Lewis X conjugated liposome. Exp Eye Res; 86 (1): 138-49.

Hirai, M., et al. (2010). E-selectin targeting to visualize tumors in vivo. Contrast Media Mol Imaging; 5 (2): 70-7.

Hirai, M., et al. (2010). Novel and simple loading procedure of cisplatin into liposomes and targeting tumor endothelial cells. Int J Pharm; 391 (1-2): 274-83.

Hirai, M., Minematsu, H., Kondo, N., Oie, K., Igarashi, K. & Yamazaki, N. (2007). Accumulation of liposome with Sialyl Lewis X to inflammation and tumor region: Application to in vivo bio-imaging. Biochem Bioph Res Co; 353 (3): 553-8.

Shimura, N., Sogawa, Y., Kawakita, Y., Ikekita, M., Yamazaki, N. & Kojima, S. (2002). Radioiodination of glycoprotein-conjugated liposomes by using the Bolton-Hunter reagent and biodistribution in tumor-bearing mice. Nucl Med Biol; 29 (4): 491-6.

Tsuruta, W., Tsurushima, H., Yamamoto, T., Suzuki, K., Yamazaki, N. & Matsumura, A. (2009). Application of liposomes incorporating doxorubicin with sialyl Lewis X to prevent stenosis after rat carotid artery injury. Biomaterials; 30 (1): 118-25.